The Science Behind Lantern Pharma

Publications

Lantern Pharma’s innovations, oncology drug-development processes and results from our research are reflected in numerous publications and posters. Sharing our results with the broader clinical and scientific community has the potential to improve our research, develop additional insights and foster new collaborations that can help us discover methods and insights that can conquer cancer.

Lantern Pharma Publications

View and display our publications.

LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency

Aditya Kulkarni, Jianli Zhou, Neha Biyani, Umesh Kathad, Partha P. Banerjee, Shiv Srivastava, Zsombor Prucsi , Kamil Solarczyk, Kishor Bhatia, Reginald B. Ewesuedo, Panna Sharma

May 6, 2024
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Preclinical Efficacy of LP-184, a Tumor Site Activated Synthetic Lethal Therapeutic, in Glioblastoma

Bachchu Lal, Aditya Kulkarni, Joseph McDermott, Rana Rais, Jesse Alt, Ying Wu, Hernando Lopez-Bertoni, Sophie Sall, Umesh Kathad, Jianli Zhou, Barbara S. Slusher, Kishor Bhatia, and John Laterra

October 13, 2023
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Conditional Dependency of LP-184 on Prostaglandin Reductase 1 Is Synthetic Lethal in Pancreatic Cancers with DNA Damage Repair Deficiencies

Diana Restifo, Joseph R McDermott, Dusica Cvetkovic, Troy Dos Santos, Charline Ogier, Aizhan Surumbayeva, Elizabeth A Handorf, Caleb Schimke, Charlie Ma, Kathy Q Cai, Anthony J Olszanski, Umesh Kathad, Kishor Bhatia, Panna Sharma, Aditya Kulkarni, and Igor Astsaturov

October 2, 2023
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LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair

Jianli Zhou, Drew Sturtevant, Cassie Love, Aditya Kulkarni, Neha Biyani, Umesh Kathad, Elizabeth Thacker, Sandeep Dave, and Kishor Bhatia

June 13, 2023
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Artificial intelligence platform, RADR®, aids in the discovery of DNA damaging agent for the ultra-rare cancer Atypical Teratoid Rhabdoid Tumors

Joseph McDermott, Drew Sturtevant, Umesh Kathad, Sudhir Varma, Jianli Zhou, Aditya Kulkarni, Neha Biyani, Caleb Schimke, William C. Reinhold, Fathi Elloumi, Peter Carr, Yves Pommier and Kishor Bhatia

October 11, 2022
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The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations

Kulkarni A., McDermott J. R., Kathad U., Modali R., Richard J. P., Sharma P., Bhatia K.

April 13, 2021
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A machine learning‐based gene signature of response to the novel alkylating agent LP‐184 distinguishes its potential tumor indications

Umesh Kathad, Aditya Kulkarni, Joseph Ryan McDermott, Jordan Wegner, Peter Carr, Neha Biyani, Rama Modali, Jean‐Philippe Richard, Panna Sharma and Kishor Bhatia

March 2, 2021
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A machine learning‑based gene signature of response to the novel alkylating agent LP‑184 distinguishes its potential tumor indications

Kathad U., Kulkarni A., McDermott J. R., Wegner J., Carr P., Biyani N., Modali R., Richard J. P., Sharma P., Bhatia K.

March 2, 2021
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Hydroxyurea derivatives of irofulven with improved antitumor efficacy

Staake M.D., Kashinatham A., McMorris T.C., Estes L.A., Kelner M.J.

April 1, 2016
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Cysteine specific targeting of the functionally distinct peroxiredoxin and glutaredoxin proteins by the investigational disulfide BNP7787

Parker A.R., Petluru P.N., Nienaber V.L., Badger J., Leverett B.D., Jair K., Sridhar V., Logan C., Ayala P.Y., Kochat H., Hausheer F.H.

March 18, 2015
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Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787

Parker A.R., Petluru P.N., Nienaber V.L., Zhao M., Ayala P.Y., Badger J., Chie-Leon B., Sridhar V., Logan C., Kochat H., Hausheer F.H.

February 4, 2015
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Phase I and pharmacologic study of BNP7787, a novel chemoprotector in patients with advanced non-small cell lung cancer

Masuda N., Negoro S., Hausheer F., Nakagawa K., Matsui K., Kudoh S., Takeda K., Yamamoto N., Yoshimura N., Ohashi Y., Fukuoka M.

May 15, 2010
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Phase I and pharmacokinetic study of the novel chemoprotector BNP7787 in combination with cisplatin and attempt to eliminate the hydration schedule

Boven E., Westerman M., van Groeningen C.J., Verschraagen M., Ruijter R., Zegers I., van der Vijgh W.J.F., Giaccone G.

April 19, 2005
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"We are in the golden age of A.I. where we are able to significantly impact the speed and precision at which we develop new drugs."
Panna Sharma
PRESIDENT & CEO, LANTERN PHARMA

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