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Taking a novel approach to drug development

AI Collaborations

Lantern Pharma collaborates with leading innovators in oncology to accelerate drug discovery and development leveraging AI-powered insights from RADR® platform, advancing precision and efficiency in cancer research.

Actuate Therapeutics

Lantern is accelerating the development of Actuate Therapeutic’s drug candidate, Elraglusib (9-ING-41), using AI insights produced by RADR®

RADR® has been demonstrating remarkable capabilities in collaboration with Actuate Therapeutics. By predicting patient response with an accuracy exceeding 88%, RADR has identified a subset of metastatic melanoma patients esistant to PD-1 therapies who may benefit from Elraglusib. The collaboration has yielded valuable insights, incorporating new data such as RNA, ctDNA, and protein biomarkers. These findings are instrumental in shaping the design of an upcoming Phase 2 clinical trial. Additionally, underlining the strategic partnership, Lantern Pharma has received equity in Actuate.

Oregon Thearpeutics

Lantern is optimizing the development of its first-in-class protein disulfide isomerase(PDI)(1) inhibitor drug candidate XCE853 in novel and targeted cancer indications.

Lantern will be leveraging RADR® AI platform to uncover biomarkers and efficacy-associated signatures of XCE853 across solid tumors that can aid in precision development. Collaborative efforts are expected to identify biomarker signatures that can be used to stratify tumors most responsive to XCE853 and guide potential future clinical development and patient selection. Oregon Therapeutics is developing XCE853 in various cancer indications, including drug-resistant ovarian and pancreatic cancer, certain hematological cancers and several pediatric cancers including CNS cancers.

TTC Oncology

Lantern is accelerating the development of TTC Oncology’s drug candidate, TTC-352 using AI insights produced by RADR®

In a collaborative effort with TTC Oncology, RADR® is accelerating the clinical development of TTC-352, a Phase 2 clinical trial-ready drug candidate designed for metastatic ER+ breast cancer. The collaboration's initial objectives encompass the identification of biomarkers or gene signatures for potential patient selection in an upcoming Phase 2 clinical trial, further characterization of TTC-352's mechanism of action, and the exploration of additional treatment indications. Notably, the terms of the collaboration grantLantern Pharma an exclusive right to license TTC-352, along with any collaboration intellectual property, during an exclusive option period.

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