The Science Behind Lantern Pharma

Posters

Lantern Pharma’s innovations, oncology drug-development processes and results from our research are reflected in numerous publications and posters. Sharing our results with the broader clinical and scientific community has the potential to improve our research, develop additional insights and foster new collaborations that can help us discover methods and insights that can conquer cancer.

View and display the results of our oncology drug testing, with in-depth statistics and conclusions regarding efficacy and potential for further development and advances in treatment.

Lantern Pharma Posters

Phase 1 Clinical Trial of LP-284 in Relapsed or Refractory B-Cell Non-Hodgkin Lymphomas and Solid Tumors

William McKean, Nihal Abdulla, Reginald Ewesuedo, Giulia Agnello, Kishor Bhatia, Jianli Zhou

SOHO 2024
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Sep 2024
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LP-184, a Novel Acylfulvene, Sensitizes Immuno-Refractory Triple Negative Breast Cancers (TNBCs) To Anti-PD1 Therapy by Affecting the Tumor Microenvironment

Aditya Kulkarni , Yong Du, Shiaw-Yih (Phoebus) Lin, Kishor Bhatia, Panna Sharma

Immuno-oncology Summit 2024
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Aug 2024
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Phase 1a/1b clinical trial of LP-284, a highly potent TP53 mutation agnostic DNA damaging agent, in patients with refractory or relapsed lymphomas and solid tumors (NCT06132503)

Jianli Zhou, Reginald Ewesuedo, Giulia Agnello, Aditya Kulkarni, Kishor Bhatia

AACR annual meeting 2024
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Apr 2024
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Targeting Homologous Recombination Deficiencies in B-Cell Non-Hodgkin’s Lymphomas with the Novel Anti-Tumor Small Molecule LP-284

Jianli Zhou, Drew Sturtevant, Reginald Ewesuedo, Kishor Bhatia

SOHO 2023 Annual Meeting
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Sep 2023
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LP-184, a clinical stage acylfulvene-derived tumor site activated small molecule, inhibits adult and pediatric CNS tumor cell growth

Aditya Kulkarni, Bachchu Lal, Joseph McDermott, John Laterra, Eric Raabe, Kishor Bhatia, Panna Sharma

SNO/ASCO CNS Cancer Conference
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Aug 2023
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In silico approaches to patient selection: Credentialing elraglusib as a novel treatment in metastatic melanoma resistant to checkpoint inhibitors

Joseph R. McDermott, Taylor Weiskittel, Brittany Borden, Ludimila Cavalcante, Francis Giles, Benedito A. Carneiro, Hu Li, Andrew P. Mazar

ASCO Annual Meeting
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Jun 2023
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Elraglusib (9-ING-41) response prediction and mechanistic discovery using iterative machine learning

Joseph McDermott, Taylor Weiskittel, Daniel Billadeau, Benedito Carneiro, Hu Li, Andrew Mazar

AACR Annual Meeting
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Apr 2023
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LP-184, an acylfulvene class small molecule therapeutic, is synthetically lethal in DNA damage repair deficient cancers

Aditya Kulkarni, Jianli Zhou, Umesh Kathad, Drew Sturtevant, Neha Biyani Kishor Bhatia, Partha Banerjee, Panna Sharma

AACR Annual Meeting
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Apr 2023
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Development of a Potent DNA Damaging Agent LP-284 for Treatment of Mantle Cell Lymphoma

J. Zhou, A. Kulkarni, C. Love, L. Happ, D. Sturtevant, N. Biyani, R.L. Peru y Colón De Portugal, K. Bhatia, S. Dave

ASH Annual Meeting & Exposition
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Dec 2022
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LP-184, an acylfulvene class small molecule therapeutic, is synthetically lethal in HR deficient and PARP inhibitor resistant triple negative breast cancer

Aditya Kulkarni, Drew Sturtevant, Neha Biyani, Laura Brullé-Soumaré, Stefano Cairo, Panna Sharma, Kishor Bhatia

San Antonio Breast Cancer Symposium
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Dec 2022
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Preclinical efficacy of LP-184, a tumor site activated synthetically lethal therapeutic, in glioblastoma

Bachchu Lal, Aditya Kulkarni, Joseph Ryan McDermott, Hernando Lopez-Bertoni, Kishor Bhatia, Panna Sharma and John Laterra

Society of Neuro Oncology Annual Meeting
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Nov 2022
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LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma

Jianli Zhou, Drew Sturtevant, Neha Biyani, Kishor Bhatia, Sandeep Dave

The Tenth Annual Meeting of the Society of Hematologic Oncology
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Sep 2022
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LP-184, a tumor site activated small molecule therapeutic, is synthetically lethal in pancreatic cancers with DNA damage repair defects

Diana Restifo, Aditya Kulkarni, Joseph McDermott, Kishor Bhatia, Panna Sharma, Igor Astsaturov

AACR Pancreatic Cancer Special Conference
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Sep 2022
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LP-184, a tumor site activated small molecule synthetic lethal therapeutic, is effective in central nervous system cancers

Aditya Kulkarni, Bachchu Lal, John Laterra, Rana Rais, Barbara Slusher, Jean-Philippe Richard, Rama Modali, Joseph McDermott, Caleb Schimke, Panna Sharma, Kishor Bhatia

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2022
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In vitro efficacy of LP-284 in hematologic cancers

Jianli Zhou, Ph.D., Neha Biyani, Ph.D., Umesh Kathad, Aditya Kulkarni, Ph.D., Joseph McDermott, Ph.D., and Kishor Bhatia, Ph.D.

American Society of Hematology (ASH) Annual Meeting
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Dec 2021
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Utility of LP-184 as a CNS-bioavailable agent in glioblastoma, having been granted orphan drug designation

Bachchu Lal, Hernando Lopez-Bertoni, Aditya Kulkarni, Joseph Ryan McDermott, Umesh Kathad, Caleb Schimke, Kishor Bhatia, Panna Sharma, Barbara Slusher, Rana Rais, and John Laterra

Society for Neuro-Oncology (SNO) Annual Meeting
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Nov 2021
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Positioning of LP-184 in DNA damage repair deficient prostate cancer

A. Kulkarni, C. Schimke, P. Banerjee, U. Kathad, K. Bhatia, P. Sharma

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2021
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Enhanced activity of LP-184 in lung cancers harboring mutations typically associated with drug resistance

A. Kulkarni , J.P. Richard , U. Kathad, M. Seddon, T. Lehman, R. Modali, P. Sharma

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2020
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Use of expression-based machine learning-derived gene signatures to predict drug sensitivity profile and identify cancer indications for LP-184

U. Kathad, A. Kulkarni, J.P. Richard, T. Lehman, R. Modali, K. Bhatia, P. Sharma, F. Elloumi, Y. Pommier, W. Reinhold

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2020
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Clinical Validation of RADR™ through identification of drug and tumor-type specific gene signatures predictive of response to approved cancer drugs

Umesh Kathad, Yuvanesh Vedaraju, Aditya Kulkarni, Kristin Haraldsdottir, Barry Henderson, Gregory Tobin, Panna Sharma, and Arun Asaithambi

American Society of Clinical Oncology (ASCO) Annual Meeting
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Jun 2019
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Establishment of a Drug-Tumor Interaction Database

Umesh Kathad, Yuvanesh Vedaraju, Aditya Kulkarni, Kristin Haraldsdottir, Barry Henderson, Gregory Tobin, Panna Sharma, Arun Asaithambi

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2019
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RADR™-guided generation of a pan-cancer gene signature associated with LP-184 sensitivity

Aditya Kulkarni, Umesh Kathad, Yuvanesh Vedaraju, Kristin Haraldsdottir, Barry Henderson, Gregory Tobin, Panna Sharma, and Arun Asaithambi

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2019
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Development and Clinical Validation of Lantern Pharma's AI engine

Umesh Kathad, Yuvanesh Vedaraju, Aditya Kulkarni, Kristin Haraldsdottir, Gregory Tobin, Panna Sharma, Arun Asaithambi

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2019
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Lantern Pharma Publications

View and display our publications.

Expanding the repertoire of Antibody Drug Conjugate (ADC) targets with improved tumor selectivity and range of potent payloads through in-silico analysis

Umesh Kathad, Neha Biyani, Raniero L. Peru, Jianli Zhou, Harry Kochat, Kishor Bhatia

August 26, 2024
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LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency

Aditya Kulkarni, Jianli Zhou, Neha Biyani, Umesh Kathad, Partha P. Banerjee, Shiv Srivastava, Zsombor Prucsi , Kamil Solarczyk, Kishor Bhatia, Reginald B. Ewesuedo, Panna Sharma

May 6, 2024
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Preclinical Efficacy of LP-184, a Tumor Site Activated Synthetic Lethal Therapeutic, in Glioblastoma

Bachchu Lal, Aditya Kulkarni, Joseph McDermott, Rana Rais, Jesse Alt, Ying Wu, Hernando Lopez-Bertoni, Sophie Sall, Umesh Kathad, Jianli Zhou, Barbara S. Slusher, Kishor Bhatia, and John Laterra

October 13, 2023
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Conditional Dependency of LP-184 on Prostaglandin Reductase 1 Is Synthetic Lethal in Pancreatic Cancers with DNA Damage Repair Deficiencies

Diana Restifo, Joseph R McDermott, Dusica Cvetkovic, Troy Dos Santos, Charline Ogier, Aizhan Surumbayeva, Elizabeth A Handorf, Caleb Schimke, Charlie Ma, Kathy Q Cai, Anthony J Olszanski, Umesh Kathad, Kishor Bhatia, Panna Sharma, Aditya Kulkarni, and Igor Astsaturov

October 2, 2023
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LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair

Jianli Zhou, Drew Sturtevant, Cassie Love, Aditya Kulkarni, Neha Biyani, Umesh Kathad, Elizabeth Thacker, Sandeep Dave, and Kishor Bhatia

June 13, 2023
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Artificial intelligence platform, RADR®, aids in the discovery of DNA damaging agent for the ultra-rare cancer Atypical Teratoid Rhabdoid Tumors

Joseph McDermott, Drew Sturtevant, Umesh Kathad, Sudhir Varma, Jianli Zhou, Aditya Kulkarni, Neha Biyani, Caleb Schimke, William C. Reinhold, Fathi Elloumi, Peter Carr, Yves Pommier and Kishor Bhatia

October 11, 2022
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The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations

Kulkarni A., McDermott J. R., Kathad U., Modali R., Richard J. P., Sharma P., Bhatia K.

April 13, 2021
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A machine learning‑based gene signature of response to the novel alkylating agent LP‑184 distinguishes its potential tumor indications

Kathad U., Kulkarni A., McDermott J. R., Wegner J., Carr P., Biyani N., Modali R., Richard J. P., Sharma P., Bhatia K.

March 2, 2021
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Hydroxyurea derivatives of irofulven with improved antitumor efficacy

Staake M.D., Kashinatham A., McMorris T.C., Estes L.A., Kelner M.J.

April 1, 2016
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Cysteine specific targeting of the functionally distinct peroxiredoxin and glutaredoxin proteins by the investigational disulfide BNP7787

Parker A.R., Petluru P.N., Nienaber V.L., Badger J., Leverett B.D., Jair K., Sridhar V., Logan C., Ayala P.Y., Kochat H., Hausheer F.H.

March 18, 2015
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Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787

Parker A.R., Petluru P.N., Nienaber V.L., Zhao M., Ayala P.Y., Badger J., Chie-Leon B., Sridhar V., Logan C., Kochat H., Hausheer F.H.

February 4, 2015
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Phase I and pharmacologic study of BNP7787, a novel chemoprotector in patients with advanced non-small cell lung cancer

Masuda N., Negoro S., Hausheer F., Nakagawa K., Matsui K., Kudoh S., Takeda K., Yamamoto N., Yoshimura N., Ohashi Y., Fukuoka M.

May 15, 2010
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Phase I and pharmacokinetic study of the novel chemoprotector BNP7787 in combination with cisplatin and attempt to eliminate the hydration schedule

Boven E., Westerman M., van Groeningen C.J., Verschraagen M., Ruijter R., Zegers I., van der Vijgh W.J.F., Giaccone G.

April 19, 2005
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"We are in the golden age of A.I. where we are able to significantly impact the speed and precision at which we develop new drugs."
Panna Sharma
PRESIDENT & CEO, LANTERN PHARMA

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