The Science Behind Lantern Pharma

Posters

Lantern Pharma’s innovations, oncology drug-development processes and results from our research are reflected in numerous publications and posters. Sharing our results with the broader clinical and scientific community has the potential to improve our research, develop additional insights and foster new collaborations that can help us discover methods and insights that can conquer cancer.

View and display the results of our oncology drug testing, with in-depth statistics and conclusions regarding efficacy and potential for further development and advances in treatment.

Lantern Pharma Posters

LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma

Jianli Zhou, Drew Sturtevant, Neha Biyani, Kishor Bhatia, Sandeep Dave

The Tenth Annual Meeting of the Society of Hematologic Oncology
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Sep 2022
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LP-184, a tumor site activated small molecule therapeutic, is synthetically lethal in pancreatic cancers with DNA damage repair defects

Diana Restifo, Aditya Kulkarni, Joseph McDermott, Kishor Bhatia, Panna Sharma, Igor Astsaturov

AACR Pancreatic Cancer Special Conference
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Sep 2022
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LP-184, a tumor site activated small molecule synthetic lethal therapeutic, is effective in central nervous system cancers

Aditya Kulkarni, Bachchu Lal, John Laterra, Rana Rais, Barbara Slusher, Jean-Philippe Richard, Rama Modali, Joseph McDermott, Caleb Schimke, Panna Sharma, Kishor Bhatia

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2022
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In vitro efficacy of LP-284 in hematologic cancers

Jianli Zhou, Ph.D., Neha Biyani, Ph.D., Umesh Kathad, Aditya Kulkarni, Ph.D., Joseph McDermott, Ph.D., and Kishor Bhatia, Ph.D.

American Society of Hematology (ASH) Annual Meeting
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Dec 2021
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Utility of LP-184 as a CNS-bioavailable agent in glioblastoma, having been granted orphan drug designation

Bachchu Lal, Hernando Lopez-Bertoni, Aditya Kulkarni, Joseph Ryan McDermott, Umesh Kathad, Caleb Schimke, Kishor Bhatia, Panna Sharma, Barbara Slusher, Rana Rais, and John Laterra

Society for Neuro-Oncology (SNO) Annual Meeting
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Nov 2021
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Positioning of LP-184 in DNA damage repair deficient prostate cancer

A. Kulkarni, C. Schimke, P. Banerjee, U. Kathad, K. Bhatia, P. Sharma

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2021
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Use of expression-based machine learning-derived gene signatures to predict drug sensitivity profile and identify cancer indications for LP-184

U. Kathad, A. Kulkarni, J.P. Richard, T. Lehman, R. Modali, K. Bhatia, P. Sharma, F. Elloumi, Y. Pommier, W. Reinhold

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2020
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Enhanced activity of LP-184 in lung cancers harboring mutations typically associated with drug resistance

A. Kulkarni , J.P. Richard , U. Kathad, M. Seddon, T. Lehman, R. Modali, P. Sharma

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2020
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Clinical Validation of RADR™ through identification of drug and tumor-type specific gene signatures predictive of response to approved cancer drugs

Umesh Kathad, Yuvanesh Vedaraju, Aditya Kulkarni, Kristin Haraldsdottir, Barry Henderson, Gregory Tobin, Panna Sharma, and Arun Asaithambi

American Society of Clinical Oncology (ASCO) Annual Meeting
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Jun 2019
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Establishment of a Drug-Tumor Interaction Database

Umesh Kathad, Yuvanesh Vedaraju, Aditya Kulkarni, Kristin Haraldsdottir, Barry Henderson, Gregory Tobin, Panna Sharma, Arun Asaithambi

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2019
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Development and Clinical Validation of Lantern Pharma's AI engine

Umesh Kathad, Yuvanesh Vedaraju, Aditya Kulkarni, Kristin Haraldsdottir, Gregory Tobin, Panna Sharma, Arun Asaithambi

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2019
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RADR™-guided generation of a pan-cancer gene signature associated with LP-184 sensitivity

Aditya Kulkarni, Umesh Kathad, Yuvanesh Vedaraju, Kristin Haraldsdottir, Barry Henderson, Gregory Tobin, Panna Sharma, and Arun Asaithambi

American Association for Cancer Research (AACR) Annual Meeting
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Apr 2019
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Preclinical efficacy of LP-184, a tumor site activated synthetically lethal therapeutic, in glioblastoma

Bachchu Lal, Aditya Kulkarni, Joseph Ryan McDermott, Hernando Lopez-Bertoni, Kishor Bhatia, Panna Sharma and John Laterra

Society of Neuro Oncology Annual Meeting - November 2022
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Lantern Pharma Publications

View and display our publications.

Artificial intelligence platform, RADR®, aids in the discovery of DNA damaging agent for the ultra-rare cancer Atypical Teratoid Rhabdoid Tumors

Joseph McDermott, Drew Sturtevant, Umesh Kathad, Sudhir Varma, Jianli Zhou, Aditya Kulkarni, Neha Biyani, Caleb Schimke, William C. Reinhold, Fathi Elloumi, Peter Carr, Yves Pommier and Kishor Bhatia

October 11, 2022
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The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations

Kulkarni A., McDermott J. R., Kathad U., Modali R., Richard J. P., Sharma P., Bhatia K.

April 13, 2021
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A machine learning‐based gene signature of response to the novel alkylating agent LP‐184 distinguishes its potential tumor indications

Umesh Kathad, Aditya Kulkarni, Joseph Ryan McDermott, Jordan Wegner, Peter Carr, Neha Biyani, Rama Modali, Jean‐Philippe Richard, Panna Sharma and Kishor Bhatia

March 2, 2021
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A machine learning‑based gene signature of response to the novel alkylating agent LP‑184 distinguishes its potential tumor indications

Kathad U., Kulkarni A., McDermott J. R., Wegner J., Carr P., Biyani N., Modali R., Richard J. P., Sharma P., Bhatia K.

March 2, 2021
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Hydroxyurea derivatives of irofulven with improved antitumor efficacy

Staake M.D., Kashinatham A., McMorris T.C., Estes L.A., Kelner M.J.

April 1, 2016
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Cysteine specific targeting of the functionally distinct peroxiredoxin and glutaredoxin proteins by the investigational disulfide BNP7787

Parker A.R., Petluru P.N., Nienaber V.L., Badger J., Leverett B.D., Jair K., Sridhar V., Logan C., Ayala P.Y., Kochat H., Hausheer F.H.

March 18, 2015
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Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787

Parker A.R., Petluru P.N., Nienaber V.L., Zhao M., Ayala P.Y., Badger J., Chie-Leon B., Sridhar V., Logan C., Kochat H., Hausheer F.H.

February 4, 2015
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Improved efficacy of acylfulvene in colon cancer cells when combined with a nuclear excision repair inhibitor

Van Midwoud P.M., Sturla S.J.

November 18, 2013
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Up-regulation of human prostaglandin reductase 1 improves the efficacy of hydroxymethylacylfulvene, an antitumor chemotherapeutic agent

Yu X., Erzinger M.M., Pietsch K.E., Cervoni-Curet F.N., Whang J., Niederhuber J., Sturla S.J.

November 1, 2012
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Phase I and pharmacologic study of BNP7787, a novel chemoprotector in patients with advanced non-small cell lung cancer

Masuda N., Negoro S., Hausheer F., Nakagawa K., Matsui K., Kudoh S., Takeda K., Yamamoto N., Yoshimura N., Ohashi Y., Fukuoka M.

May 15, 2010
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Enantioselective total synthesis of (−)-Acylfulvene and (−)- Irofulven

Siegel D.S., Piizzi G., Piersanti G., Movassaghi M.

November 25, 2009
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Influence of irofulven, a transcription-coupled repair-specific antitumor agent, on RNA polymerase activity, stability and dynamics in living mammalian cells

Escargueil A.E., Poindessous V., Soares D.G., Sarasin A., Cook P.R., Larsen A.K.

April 15, 2008
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Phase I and pharmacokinetic study of the novel chemoprotector BNP7787 in combination with cisplatin and attempt to eliminate the hydration schedule

Boven E., Westerman M., van Groeningen C.J., Verschraagen M., Ruijter R., Zegers I., van der Vijgh W.J.F., Giaccone G.

April 19, 2005
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Activity of irofulven against human pancreatic carcinoma cell lines in vitro and in vivo

Van Laar E.S., Roth S., Weitman S., MacDonald J.R., Waters S.J.

January 1, 2004
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Apoptosis induction by the dual-action DNA- and protein-reactive antitumor drug irofulven is largely Bcl-2-independent

Herzig M.C., Trevino A.V., Liang H., Salinas R., Waters S.J., MacDonald J.R., Woynarowska B.A., Woynarowski J.M.

February 15, 2003
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Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways

Jaspers N.G., Raams A., Kelner M.J., Ng J.M., Yamashita Y.M., Takeda S., McMorris T.C., Hoeijmakers J.H.

December 5, 2002
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Enhanced antitumor activity of irofulven in combination with antimitotic agents

Michael J. Kelner, Trevor C. McMorris, Rafael J. Rojas, Nicole A. Trani, Tami R. Velasco, Leita A. Estes and Pharnuk Suthipinijtham

August 1, 2002
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Efficacy of MGI 114 (6-hydroxymethylacylfulvene, HMAF) against the mdr1/gp170 metastatic MV522 lung carcinoma xenograft

Kelner M.J., McMorris T.C., Estes L., Samson K.M., Bagnell R.D., Taetle R.

May 1, 1998
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Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents

Kelner M.J., McMorris T.C., Estes L., Wang W., Samson K.M., Taetle R.

June 1, 1996
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Efficacy of acylfulvene illudili analogues against a metastatic lung carcinoma MV 522 xenograft nonresponsive to traditional anticancer agents: retention of activity against various mdr phenotypes and unusual cytotoxicity against ERCC 2

Efficacy of acylfulvene illudili analogues against a metastatic lung carcinoma MV 522 xenograft nonresponsive to traditional anticancer agents: retention of activity against various mdr phenotypes and unusual cytotoxicity against ERCC 2 and ERCC 3 DNA helicase-deficient cells

Kelner M.J., Mcmorris T.C., Estes L.A., Starr R.J., Rutherford M., Montoya M., Samson K.M., Taetle R.

November 1, 1995
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Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells. Unusually high sensitivity of ERCC2 and ERCC3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agents

Kelner M.J., McMorris T.C., Estes L., Rutherford M., Montoya M., Goldstein J., Samson K., Starr R., Taetle R.

July 19, 1994
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"We are in the golden age of A.I. where we are able to significantly impact the speed and precision at which we develop new drugs."
Panna Sharma
PRESIDENT & CEO, LANTERN PHARMA

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